萘法唑酮盐酸盐

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中文名	萘法唑酮盐酸盐
英文名	nefazodone hydrochloride
中文别名	盐酸奈法唑酮 \| 氘代盐酸奈法唑酮-d5
英文别名	更多

描述

Nefazodone 盐酸盐是一种抗抑郁药物。

相关类别

信号通路 >>

G 蛋白偶联受体/G 蛋白 >>

5-HT受体

信号通路 >>

神经信号通路 >>

5-HT受体

信号通路 >>

G 蛋白偶联受体/G 蛋白 >>

肾上腺素能受体

研究领域 >>

神经疾病

溶解度

体外：

DMSO：17.5 mg / mL（34.55 mM;需要超声波和加热）

储备液

1 mM	1.9745 mL	9.8723 mL	19.7445 mL
5 mM	0.3949 mL	1.9745 mL	3.9489 mL
10 mM	0.1974 mL	0.9872 mL	1.9745 mL

存储

粉末	-20℃下	3年
	4℃下	2年
在溶剂中	-80℃下	6个月
	-20℃下	1个月

运输

室温;可能会有所不同

SMILES

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.[H]Cl

参考文献

[1]. Bengi Uslu, et al. Electrochemical characterisation of nefazodone hydrochloride and voltammetric determination of the drug in pharmaceuticals and human serum. Analytica Chimica Acta Volume 462, Issue 1, 26 June 2002, Pages 49–57

[2]. SHEN Wei-Yang, et al. Determination of Nefazodone Hydrochloride Tablets by HPLC. Chinese Journal of Pharmaceuticals, 2003-10

相关活性
小分子

沸点	599.6?C at 760 mmHg
熔点	186-188?C
分子式	C₂₅H₃₃Cl₂N₅O₂
分子量	506.46800
闪点	316.4?C
精确质量	505.20100
PSA	55.53000
LogP	4.35680
外观性状	白色固体
储存条件	Desiccate at RT
水溶解性	DMSO: ~11?mg/mL at?60?°C

萘法唑酮盐酸盐MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
安全声明 (欧洲)	22-24/25
危险品运输编码	NONH for all modes of transport
WGK德国	3

5-乙基-4-(2-苯氧基乙基…

95885-13-5

1-(3-氯苯基)-4-(3-…

52605-52-4

~63%

萘法唑酮盐酸盐

82752-99-6

文献：Mead Johnson and Company Patent: US4487773 A1, 1984 ; US 4487773 A

萘法唑酮盐酸盐上游产品? 2
CAS号95885-13-5 5-乙基-4-(2-苯氧基乙基… CAS号52605-52-4 1-(3-氯苯基)-4-(3-…
萘法唑酮盐酸盐下游产品? 0

萘法唑酮盐酸盐上游产品? 2

CAS号95885-13-5
5-乙基-4-(2-苯氧基乙基…

CAS号52605-52-4
1-(3-氯苯基)-4-(3-…

萘法唑酮盐酸盐下游产品? 0

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

J. Chromatogr. A. 1374 , 122-33, (2014)

The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab…

The relation between changes in patients’ interpersonal impact messages and outcome in treatment for chronic depression.

J. Consult. Clin. Psychol. 80(3) , 354-64, (2012)

Interpersonal theories posit that chronically depressed individuals have hostile and submissive styles in their social interactions, which may undermine their interpersonal effectiveness and maintain …

Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug.

Drug Metab. Dispos. 36(6) , 1016-29, (2008)

In vitro metabolism/bioactivation of structurally related central nervous system agents nefazodone (hepatotoxin) and aripiprazole (nonhepatotoxin) were undertaken in human liver microsomes in an attem…

MFCD00865396

2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one,hydrochloride

Nefazodone Hydrochloride

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萘法唑酮盐酸盐

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