螺旋霉素

中文名	螺旋霉素
英文名	Spiramycin
英文别名	更多

描述

Spiramycin 是由链霉菌 (Streptomyces ambofaciens) 产生的临床上重要的 16-元大环内酯类抗生素。

相关类别

信号通路 >>

抗感染 >>

细菌

研究领域 >>

感染

靶点

Bacterial[1]

溶解度

体外：

DMSO：≥100mg / mL（118.62 mM）

* “≥”表示可溶，但饱和度未知。

体内：1。逐个添加每种溶剂：10％DMSO 90％玉米油溶解度：≥2.5mg / mL（2.97 mM）;澄清溶液2.逐个加入每种溶剂：10％DMSO 90％（20％SBE-β-CD在盐水中）溶解度：≥2.5mg/ mL（2.97mM）;澄清溶液3.逐个添加每种溶剂：10％DMSO 40％PEG300 5％吐温-80 45％盐水溶解度：≥2.5mg/ mL（2.97mM）;明确解决方案

储备液

1 mM	1.1862 mL	5.9308 mL	11.8617 mL
5 mM	0.2372 mL	1.1862 mL	2.3723 mL
10 mM	0.1186 mL	0.5931 mL	1.1862 mL

存储

粉末	-20°C	3年
?	4°C	2年
在溶剂中	-80°C	6月
?	-20°C	1月

运输

室温;可能会有所不同

SMILES

O[C@H](C1)[C@H](OC)[C@@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](O)(C)C3)[C@@H](C)O2)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@@H]4O[C@H](C)[C@@H](N(C)C)CC4)/C=C/C=C/C[C@@H](C)OC1=O

参考文献

[1]. Nguyen HC, et al. Post-PKS tailoring steps of the spiramycin macrolactone ring in Streptomyces ambofaciens. Antimicrob Agents Chemother. 2013 Aug;57(8):3836-42.

相关活性
小分子

密度	1.2±0.1 g/cm3
沸点	913.7±65.0 °C at 760 mmHg
分子式	C₄₃H₇₄N₂O₁₄
分子量	843.053
闪点	506.4±34.3 °C
精确质量	842.513977
LogP	3.06
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.550

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xi
风险声明 (欧洲)	36/37/38
安全声明 (欧洲)	26-36-24/25
危险品运输编码	NONH for all modes of transport
WGK德国	1
RTECS号	WG9400000
海关编码	29419090

Regulation of the biosynthesis of the macrolide antibiotic spiramycin in Streptomyces ambofaciens.

J. Bacteriol. 192(21) , 5813-21, (2010)

Streptomyces ambofaciens synthesizes the macrolide antibiotic spiramycin. The biosynthetic gene cluster for spiramycin has been characterized for S. ambofaciens. In addition to the regulatory gene srm…

A spicamycin derivative (KRN5500) provides neuropathic pain relief in patients with advanced cancer: a placebo-controlled, proof-of-concept trial.

J. Pain Symptom Manage. 43(4) , 679-93, (2012)

Neuropathic pain in patients with cancer can be difficult to treat effectively.The purpose of the study was to determine safety and efficacy of KRN5500, a novel, spicamycin-derived, nonopioid analgesi…

Influences of two antibiotic contaminants on the production, release and toxicity of microcystins

Ecotoxicol. Environ. Saf. 77 , 79-87, (2012)

The influences of spiramycin and amoxicillin on the algal growth, production and release of target microcystins (MCs), MC-LR, MC-RR and MC-YR, in Microcystis aeruginosa were investigated through the s…

[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2R,5S,6S)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-hydroxy-5-methoxy-9,16-dimethyl-2-oxooxacyclohexadeca-11,13-dien-7-yl]acetaldehyde (non-preferred name)

Leucomycin

Foromacidin

Provamycin

[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2R,5S,6S)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-hydroxy-5-methoxy-9,16-dimethyl-2-oxooxacyclohexadeca-11,13-dien-7-yl]acetaldehyde

Spiramycin I

Rovamycin

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