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| 描述 |
Kavain是一类从 Piper methysticum 中分离出来的卡瓦酸内酯，对动物和人类具有抗焦虑和镇静作用。Kavain 可以正调控 GABAA 受体。 |
|---|---|
| 体外研究 |
双电极电压钳技术用于表征主要抗焦虑kavalactone，Kavain在人重组α1β2，β2γ2L，αxβ2γ2L，α1βxγ2L和α4β2δγ-氨基丁酸A型受体（GABAARs）中的功能特性。非洲爪蟾卵母细胞。无论亚基组成如何，Kavain都能正向调节所有受体，但α4β2δ的增强程度大于α1β2γ2LGABAARs。KKAAVAIN的调节作用不受氟马西尼的影响，表明Kavain不通过经典的苯二氮卓结合位点增强GABAAR。先前已显示β3N265M点突变显着降低麻醉敏感性，也减少了Kavain介导的增强作用[1]。 |
| 存储 |
请将产品存放在分析证书中的建议条件下。
|
| 运输 |
室温 |
| SMILES |
O=C1C=C(OC)CC(/C=C/C2=CC=CC=C2)O1 |
| 参考文献 |
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| 密度 | 1.2±0.1 g/cm3 |
|---|---|
| 沸点 | 432.6±45.0 °C at 760 mmHg |
| 熔点 | 142-148?C |
| 分子式 | C14H14O3 |
| 分子量 | 230.259 |
| 闪点 | 184.6±23.3 °C |
| 精确质量 | 230.094299 |
| PSA | 35.53000 |
| LogP | 1.69 |
| 蒸汽压 | 0.0±1.0 mmHg at 25°C |
| 折射率 | 1.565 |
| 符号 |
GHS07 |
|---|---|
| 信号词 |
Warning |
| 危害声明 |
H302 |
| 个人防护装备 |
dust mask type N95 (US);Eyeshields;Gloves |
| 危害码 (欧洲) |
Xn:Harmful; |
| 风险声明 (欧洲) |
R22 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
|
Fatal kavalactone intoxication by suicidal intravenous injection. Forensic Sci. Int. 249 , e7-11, (2015)
Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxioly…
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Kavalactones fail to inhibit alcohol dehydrogenase in vitro. Phytomedicine 13(3) , 192-5, (2006)
In recent years, Kava kava (Piper methysticum, Forst. f., Piperaceae), a folkloric beverage and popular herbal remedy, has been implicated in a number of liver failure cases. Many hypotheses as to the…
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Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro. Phytother Res. 25(3) , 417-23, (2011)
While cases of severe kava hepatotoxicity have been reported, studies examining the toxicity of individual kavalactones are limited. The present study examined the in vitro hepatotoxicity of kavain, m…
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DL-Kawain |
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2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[(E)-2-phenylethenyl]- |
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4-Methoxy-6-[(E)-2-phenylvinyl]-5,6-dihydro-2H-pyran-2-one |
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trans-5,6-Dihydro-4-methoxy-6-(2-phenylethenyl)-2H-pyran-2-one,DL-Kawain |
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KAVAIN,DL |
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UNII:5L1NI60TGB |
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Kawain,DL |
|
Kawain |
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Kavain |
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2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-, (E)-(±)- |
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MFCD00270446 |
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Kawain, DL- |
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2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl- |
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Kavain, dl- |
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DL-KAVAIN |
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