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醋酸氟轻松
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| 中文名 |
醋酸氟轻松 |
|---|---|
| 英文名 |
Fluocinolone Acetonide Acetate |
| 中文别名 |
氟轻松醋酸酯 | 肤万酯氧-6α,9-二氟-11β-羟基-16α,17-[(1-甲基亚乙基)双(氧)]娠烷-1,4-二烯-3,20-二酮 | 醋酸肤轻松 |
| 英文别名 |
更多 |
| 描述 |
Fluocinonide (Vanos)是糖皮质激素类固醇，具有抗炎活性，可作用于皮肤疾病。 |
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| 相关类别 |
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| 溶解度 |
体外：
DMSO：≥100mg / mL（202.22 mM） * “≥”表示可溶，但饱和度未知。
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| 储备液 |
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| 存储 |
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| 运输 |
室温;可能会有所不同 |
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| SMILES |
O=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C5)(OC(C)(C)O1)[C@]25C)COC(C)=O |
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| 参考文献 |
[1]. https://en.wikipedia.org/wiki/Fluocinonide
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| 相关活性 小分子 |
氢化可的松 | 米非司酮 | 皮质酮 | 泼尼松 | 原人参三醇 | 氟替卡松丙酸酯 | 曲安西龙 | 可的松 | AL 082D06 | 糖皮质激素受体激动剂 | Mapracorat | 环索奈德 | 丙酸倍氯米松 | 丙酸氯倍他索 | Cort108297 |
| 密度 | 1.3±0.1 g/cm3 |
|---|---|
| 沸点 | 591.1±50.0 °C at 760 mmHg |
| 熔点 | 309?C |
| 分子式 | C26H32F2O7 |
| 分子量 | 494.525 |
| 闪点 | 311.3±30.1 °C |
| 精确质量 | 494.211609 |
| PSA | 99.13000 |
| LogP | 3.36 |
| 外观性状 | 白色结晶粉末 |
| 蒸汽压 | 0.0±3.8 mmHg at 25°C |
| 折射率 | 1.560 |
| 计算化学 |
1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:9 4.可旋转化学键数量:4 5.互变异构体数量:2 6.拓扑分子极性表面积:99.1 7.重原子数量:35 8.表面电荷:0 9.复杂度:1070 10.同位素原子数量:0 11.确定原子立构中心数量:9 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
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醋酸氟轻松毒性英文版
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| 符号 |
GHS06, GHS08 |
|---|---|
| 信号词 |
Danger |
| 危害声明 |
H300-H361 |
| 警示性声明 |
Missing Phrase – N15.00950417-P280 |
| 危害码 (欧洲) |
T+: Very toxic; |
| 风险声明 (欧洲) |
R28 |
| 安全声明 (欧洲) |
22-25-28-36/37/39-45 |
| 危险品运输编码 | UN 2811 6.1/PG 2 |
| WGK德国 | 3 |
| RTECS号 | TU3831000 |
| 包装等级 | I |
| 危险类别 | 6.1(a) |
| 海关编码 | 2937210000 |
| 醋酸氟轻松上游产品? 3 | |
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| 醋酸氟轻松下游产品? 1 | |
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| 海关编码 | 2937210000 |
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Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis. Journal. of. Drugs in. Dermatology. 10(2) , 171-6, (2011)
To determine the effect a novel formulation of fluocinonide cream on skin barrier function in subjects with atopic dermatitis.The authors performed an open-label, investigator-blinded, side-by-side, c…
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Urticarial hypersensitivity reaction caused by temozolomide. Journal. of. Drugs in. Dermatology. 9(9) , 1142-4, (2010)
Temozolomide is an oral alkylating agent approved for the treatment of glioblastoma and anaplastic astrocytoma, and is currently under clinical investigation for the treatment of brain metastases from…
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In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle. Journal. of. Drugs in. Dermatology. 7(1) , 28-32, (2008)
Prolonged topical corticosteroid use is often associated with atrophic skin changes. This trial compared signs of skin atrophy related to 3 super-high-potency corticosteroids: fluocinonide 0.1% cream,…
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2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluor-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxo |
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Ethylacetat |
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acétate de 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-4a,6a,8,8-tétraméthyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodécahydro-6bH-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-6 |
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16a,17a-Isopropylidene-6a-fluorotriamcinolone 21-Acetate |
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6a,9-Difluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone 21-Acetate |
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FLUOCINONIDE |
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2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-ox |
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2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-[(acetyloxy)acetyl]-4b,12-difluoro-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-4a,6a,8,8-tetramethyl-, (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)- |
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2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-[2-(acetyloxy)acetyl]-4b,12-difluoro-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-4a,6a,8,8-tetramethyl-, (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)- |
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2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluor-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethylacetat |
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21-Acetoxy-6a,9a-difluoro-11b-hydroxy-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione |
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oethyl acetate |
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21-(Acetyloxy)-6a,9-difluoro-11b-hydroxy-16a,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione |
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Topsym |
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acétate de 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-4a,6a,8,8-tétraméthyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodécahydro-6bH-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-6b-yl]-2-oxoéthyle |
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2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl acetate |
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