醋酸甲泼尼龙

中文名	醋酸甲泼尼龙
英文名	methylprednisolone acetate
中文别名	6A-甲基泼尼松龙醋酸酯 \| 甲基强的龙醋酸盐 \| 6Alpha-甲基波尼松龙21-醋酸 \| 甲基泼尼松龙醋酸酯
英文别名	更多

描述	醋酸甲基强的松龙是一种强的松酮衍生物，是一种皮质类固醇激素。醋酸甲基强的松龙可减轻关节炎和其他关节疾病在体内引起的疼痛和肿胀[1][2]。
相关类别	研究领域 >> 炎症/免疫信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
体内研究	醋酸甲基强的松龙（30mg/kg，肌肉注射；连续10天额外口服剂量为13mg/kg）与LPS联合诱导股骨头早期AVN的典型特征[2]。动物模型：甲基强的松龙和脂糖诱导的小鼠股骨头坏死模型[2]剂量：30mg/kg；13mg/kg，连续10天给药：30mg/kg，肌肉注射；连续10天口服13mg/kg的额外剂量会导致7周后软骨细胞变性和纤维软骨表达。增加股骨头中CD31和VEGF-R2标记物的密度。
存储	请将产品存放在分析证书中的建议条件下。
运输	室温
参考文献	[1]. Ha Thi -Ngan Le, et al. A mouse model of osteonecrotic femoral head induced by methylprednisolone and liposaccharide. Biomedical Research and Therapy?volume?3, Article?number:?12?(2016)? [2]. Luis M Franco,et al. Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses. J Exp Med. 2019 Feb 4;216(2):384-406.

密度	1.3±0.1 g/cm3
沸点	582.5±50.0 °C at 760 mmHg
熔点	206?C
分子式	C₂₄H₃₂O₆
分子量	416.507
闪点	196.5±23.6 °C
精确质量	416.219879
PSA	100.90000
LogP	3.08
外观性状	灰白色固体
蒸汽压	0.0±3.7 mmHg at 25°C
折射率	1.580
储存条件	Refrigerator
分子结构	1、摩尔折射率：109.67 2、摩尔体积（cm³/mol）：329.3 3、等张比容（90.2K）：893.5 4、表面张力（dyne/cm）：54.1 5、极化率（10-24cm3）：43.47
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:2 3.氢键受体数量:6 4.可旋转化学键数量:4 5.互变异构体数量:6 6.拓扑分子极性表面积101 7.重原子数量:30 8.表面电荷:0 9.复杂度:858 10.同位素原子数量:0 11.确定原子立构中心数量:8 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1

醋酸甲泼尼龙MSDS英文版

醋酸甲泼尼龙毒性英文版

符号	GHS08
信号词	Warning
危害声明	H361
警示性声明	P201-P308 + P313
危害码 (欧洲)	Xn
风险声明 (欧洲)	63-62
安全声明 (欧洲)	S24/25
危险品运输编码	NONH for all modes of transport
WGK德国	3

醋酸甲泼尼龙上游产品? 4
CAS号53-06-5 可的松 CAS号3386-04-7 11-beta,21-dihy… CAS号117888-35-4 (20Ξ)-11β-hydro… CAS号3607-68-9 17α,20,20,21-bi…
醋酸甲泼尼龙下游产品? 3
CAS号83-43-2 6α-甲基泼尼松龙 CAS号359-80-8 Pregna-1,4-dien… CAS号382-52-5 Pregna-1,4-dien…

醋酸甲泼尼龙上游产品? 4

CAS号53-06-5
可的松

CAS号3386-04-7
11-beta,21-dihy…

CAS号117888-35-4
(20Ξ)-11β-hydro…

CAS号3607-68-9
17α,20,20,21-bi…

醋酸甲泼尼龙下游产品? 3

CAS号83-43-2
6α-甲基泼尼松龙

CAS号359-80-8
Pregna-1,4-dien…

CAS号382-52-5
Pregna-1,4-dien…

Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling.

J. Transl. Med. 12 , 334, (2014)

Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to the various effects of steroids on multi-system pathways involved into osteoblast differentiat…

Cholesterol- and lanolin-rich diets may protect against steroid-induced osteonecrosis in rabbits.

Acta Orthop. 84(6) , 593-7, (2013)

It remains controversial how hypercholesterolemia influences the development of steroid-induced osteonecrosis (ON). We investigated the role of hypercholesterolemia induced by a cholesterol-rich diet …

Notes from the field: Department of Defense response to a multistate outbreak of fungal meningitis–United States, October 2012.

MMWR Morb. Mortal. Wkly. Rep. 62(38) , 800-1, (2013)

On October 1, 2012, the Department of Defense (DoD) learned of a multistate outbreak of fungal meningitis in persons who received injections of methylprednisolone acetate (MPA) from a single compoundi…

2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethylacetat

6-METHYLPREDNISOLONE ACETATE

(6α,11β)-11,17-Dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate

Methylprednisolone acetate

21-Acetoxy-11b,17-dihydroxy-6a-methylpregna-1,4-diene-3,20-dione

(6a,11b)-21-(Acetyloxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione

6a-Methylprednisolone 21-Acetate

CH3CO2CH(CH3)CH2OCH3

Depo-methylprednisolone

MFCD00144786

EINECS 200-171-3

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6α,11β)-

2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl acetate

acétate de 2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-triméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yl]-2-oxoéthyle

6α-Methyl Prednisolone 21-Acetate

6α-Methylprednisolone 21-acetate

Solsolona

Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, 21-acetate (8CI)

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