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| 描述 |
Rhoifolin 是从琯溪蜜柚 (Citrus grandis) 叶子分离的黄酮糖苷。 Rhoifolin 通过增强脂联素分泌，胰岛素受体-β (insulin receptor-β) 的酪氨酸磷酸化和 GLUT4 易位有益于糖尿病并发症。 Rhoifolin 通过 RANKL 诱导的 NF-κB 和 MAPK 途径改善钛颗粒刺激的骨溶解并减弱破骨细胞生成。 |
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| 相关类别 |
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| 靶点 |
NF-κB
insulin receptor-β
MAPK
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| SMILES |
O=C(C=C(C1=CC=C(O)C=C1)OC2=CC(O[C@H](O[C@H](CO)[C@@H](O)[C@@H]3O)[C@@H]3O[C@@](O[C@@H](C)[C@H](O)[C@H]4O)([H])[C@@H]4O)=C5)C2=C5O |
| 参考文献 |
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| 密度 | 1.7±0.1 g/cm3 |
|---|---|
| 沸点 | 916.5±65.0 °C at 760 mmHg |
| 分子式 | C27H30O14 |
| 分子量 | 578.519 |
| 闪点 | 305.4±27.8 °C |
| 精确质量 | 578.163574 |
| PSA | 228.97000 |
| LogP | 1.72 |
| 蒸汽压 | 0.0±0.3 mmHg at 25°C |
| 折射率 | 1.726 |
| 储存条件 | 0-6°C |
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| 个人防护装备 |
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危害码 (欧洲) |
Xi |
| 安全声明 (欧洲) |
24/25 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
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Study on impurities in naringin extracted from Citrus grandis ‘tomentosa’. Zhong Yao Cai 35(1) , 56-61, (2012)
To investigate the impurities in naringin extracted from Citrus grandis ‘Tomentosa’.High performance liquid chromatographies coupled with photodiode array and electrospray ionization mass spectrometry…
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Determination of rhoifolin and daidzin in human plasma by high-performance liquid chromatography. J. Chromatogr. B, Biomed. Appl. 655(2) , 300-4, (1994)
A method for determining flavonoids in human plasma is presented for application to pharmacokinetic studies of two flavonoids, rhoifolin and daidzin. Isocratic reversed-phase high-performance liquid c…
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[Studies on antibacterial constituents of Discocleidion rufescens (2)]. Zhongguo Zhong Yao Za Zhi 34 , 1377-1380, (2009)
To screen effective constituents of Discocleidion rufescens against bacteria.Compounds were isolated by bioassay-guided fractionation method with various chromatographic methods and their structures w…
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Apigenin-7-O-neohesperidoside |
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Apigenin-7-neohesperidoside |
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RHOIFOLOSIDE |
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7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-on |
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4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-hydroxyphenyl)- |
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7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxyméthyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}tétrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphényl)-4H-chromén-4-one |
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Apigenin 7-O-neo-hesperidoside |
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5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside |
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4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-oxy]-5-hydroxy-2-(4-hydroxyphenyl)- |
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5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside |
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apigenin 7-O-neohesperidoside |
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Rhoifolin |
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Apigenin-7-rhamnoglucoside |
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5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside |
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7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one |
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4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)- |
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