金缕梅单宁

中文名	金缕梅单宁
英文名	hamamelitannin
中文别名	金缕梅丹宁酸
英文别名	更多

描述	Hamamelitannin 是从 Hamamelis virginiana 树皮中提取的多酚，是一种群体感应 (QS) 抑制剂。Hamamelitannin 通过影响肽聚糖生物合成和 eDNA 释放增加金黄色葡萄球菌生物膜的抗生素敏感性。
相关类别	研究领域 >> 感染信号通路 >> 抗感染 >> 细菌
体外研究	金缕梅素显示对结肠癌细胞特异的细胞毒活性〔3〕。
存储	请将产品存放在分析证书中的建议条件下。
运输	室温
SMILES	O=C[C@]([C@@H]([C@@H](COC(C1=CC(O)=C(O)C(O)=C1)=O)O)O)(COC(C2=CC(O)=C(O)C(O)=C2)=O)O
参考文献	[1]. Kiran MD, et al. Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol. 2008 May;73(5):1578-86. [2]. Cobrado L, et al. In vivo antibiofilm effect of cerium, chitosan and hamamelitannin against usual agents of catheter-related bloodstream infections. J Antimicrob Chemother. 2013 Jan;68(1):126-30. [3]. Sánchez-Tena S, et al. Hamamelitannin displays specific cytotoxic activity against colon cancer cells. J Nat Prod. 2012 Jan 27;75(1):26-33.

密度	1.8±0.1 g/cm3
沸点	941.7±65.0 °C at 760 mmHg
熔点	145-147?C
分子式	C₂₀H₂₀O₁₄
分子量	484.364
闪点	329.0±27.8 °C
精确质量	484.085297
PSA	243.90000
LogP	2.91
蒸汽压	0.0±0.3 mmHg at 25°C
折射率	1.746

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3

Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo.

Antimicrob. Agents Chemother. 55 , 2655-2661, (2011)

Although the exact role of quorum sensing (QS) in various stages of biofilm formation, maturation, and dispersal and in biofilm resistance is not entirely clear, the use of QS inhibitors (QSI) has bee…

Hamamelitannin from witch hazel (Hamamelis virginiana) displays specific cytotoxic activity against colon cancer cells.

J. Nat. Prod. 75 , 26-33, (2012)

Hamamelis virginiana (witch hazel) bark is a rich source of condensed and hydrolyzable tannins reported to exert a protective action against colon cancer. The present study characterizes different wit…

Cerium, chitosan and hamamelitannin as novel biofilm inhibitors?

J. Antimicrob. Chemother. 67 , 1159-62, (2012)

The colonization of indwelling medical devices and subsequent biofilm formation represents a global challenge since it promotes the persistence of infection and contributes to antimicrobial resistance…

HAMAMELOFURANOSE 2′,5-DIGALLATE

2′,5-DigalloylhaMaMelofuranose

2,3-Digalloylglucose

[(2R,3R,4R)-3,4,5-Trihydroxytetrahydrofuran-2,4-diyl]bis(methylen)bis(3,4,5-trihydroxybenzoat)

2-C-[[(3,4,5-Trihydroxybenzoyl)oxy]methyl]-D-ribofuranose 5-(3,4,5-trihydroxybenzoate)

Bis(3,4,5-trihydroxybenzoate) de [(2R,3R,4R)-3,4,5-trihydroxytétrahydrofurane-2,4-diyl]bis(méthylène)

2′,5-digalloylhamamelose

hamamelitanin

Hamamelitannin

[(2R,3R,4R)-3,4,5-Trihydroxytetrahydrofuran-2,4-diyl]bis(methylene) bis(3,4,5-trihydroxybenzoate)

O5-Galloyl-2-galloyloxymethyl-D-ribose

5-O-(3,4,5-Trihydroxybenzoyl)-2-C-{[(3,4,5-trihydroxybenzoyl)oxy]methyl}-D-ribofuranose

D-Ribofuranose, 2-C-[[(3,4,5-trihydroxybenzoyl)oxy]methyl]-, 5-(3,4,5-trihydroxybenzoate)

2-C-(Hydroxymethyl)-D-ribofuranose 2′,5-Digallate

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