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| 描述 |
Tiliroside 是一种糖苷类黄酮，具有抗糖尿病作用。Tiliroside 是 α-淀粉酶 (α-amylase) 的非竞争性抑制剂，Ki 值为 84.2 μM。Tiliroside 抑制胃肠道中碳水化合物的消化和葡萄糖的吸收。 |
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| 相关类别 |
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| 体外研究 |
替罗西德体外抑制胰腺α-淀粉酶（IC50=0.28?mM）[1]。 |
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| 体内研究 |
在雄性ICR小鼠中，替罗西德给药组显著抑制餐后血糖水平的升高[1]。 |
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| 溶解度 |
In Vitro:
DMSO : 250 mg/mL (420.51 mM; Need ultrasonic) In Vivo:
1. 请依序添加每种溶剂：?10% DMSO ?? 40% PEG300 ?? 5% Tween-80 ?? 45% saline Solubility: ≥ 2.08 mg/mL (3.50 mM); Clear solution 2. 请依序添加每种溶剂：?10% DMSO ?? 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.08 mg/mL (3.50 mM); Clear solution 3. 请依序添加每种溶剂：?10% DMSO ?? 90% corn oil Solubility: ≥ 2.08 mg/mL (3.50 mM); Clear solution
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| 储备液 |
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| 运输 |
室温 |
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| SMILES |
O=C1C(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)COC(/C=C/C3=CC=C(O)C=C3)=O)=C(C4=CC=C(O)C=C4)OC5=CC(O)=CC(O)=C51.[E] |
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| 参考文献 |
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| 密度 | 1.7±0.1 g/cm3 |
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| 沸点 | 943.9±65.0 °C at 760 mmHg |
| 熔点 | 257-260?C |
| 分子式 | C30H26O13 |
| 分子量 | 594.520 |
| 闪点 | 311.9±27.8 °C |
| 精确质量 | 594.137329 |
| PSA | 216.58000 |
| LogP | 3.83 |
| 蒸汽压 | 0.0±0.3 mmHg at 25°C |
| 折射率 | 1.759 |
| 储存条件 | 2-8°C |
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银锻苷毒性英文版
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| 危险品运输编码 | NONH for all modes of transport |
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Investigation into biologically active constituents of Geum rivale L. Acta Pol. Pharm. 70(1) , 111-4, (2013)
Aerial and underground parts of Geum rivale (Rosaceae) were investigated. Tiliroside, gallic acid, ellagic acid and a sterol fraction were isolated from aerial parts of the plant. The sterol fraction …
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New phenolic compounds with anti-adipogenic activity from the aerial parts of Pulsatilla koreana. Planta Med. 78(16) , 1783-6, (2012)
Three new phenolic compounds, pulsatillosides A (1), B (2), and C (3), were isolated from the aerial parts of Pulsatilla koreana, together with two known flavonoid glycosides, trans-tiliroside (4) and…
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Tyrosinase inhibitory effect and inhibitory mechanism of tiliroside from raspberry. J. Enzyme Inhib. Med. Chem. 24(5) , 1154-60, (2009)
Tiliroside was found to inhibit both monophenolase and diphenolase activity of mushroom tyrosinase. The lag time of tyrosine oxidation catalyzed by mushroom tyrosinase was obviously lengthened; 0.337 …
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5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-O-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-b-D-glucopyranoside |
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[(2R,3S,4S,5R,6S)-6-{[5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl]oxy}-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]methyl-(2E)-3-(4-hydroxyphenyl)acrylat |
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Kaempferol-3-Glucoside-6”-p-coumaroyl |
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tiliroside |
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[(2R,3S,4S,5R,6S)-6-{[5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl]oxy}-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]methyl (2E)-3-(4-hydroxyphenyl)acrylate |
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4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[[6-O-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-β-D-glucopyranosyl]oxy]- |
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(2E)-3-(4-Hydroxyphényl)acrylate de [(2R,3S,4S,5R,6S)-6-{[5,7-dihydroxy-2-(4-hydroxyphényl)-4-oxo-4H-chromén-3-yl]oxy}-3,4,5-trihydroxytétrahydro-2H-pyran-2-yl]méthyle |
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trans-tiliroside |
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6-O-[(2E)-3-(4-Hydroxyphényl)-2-propènan-1-oyl]-β-D-glucopyranoside de 5,7-dihydroxy-2-(4-hydroxyphényl)-4-oxo-4H-chromén-3-yle |
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5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-O-[(2E)-3-(4-hydroxyphenyl)-2-propenoyl]-β-D-glucopyranoside |
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6′-O-trans-p-CouMaroylastragalin |
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5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-O-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-β-D-glucopyranoside |
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4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[[6-O-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-β-D-glucopyranosyl]oxy]- |
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5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl-6-O-[(2E)-3-(4-hydroxyphenyl)-2-propenoyl]-β-D-glucopyranoside |
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