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长春氟宁

长春氟宁

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?长春氟宁名称
















中文名

长春氟宁
英文名

Vinflunine
英文别名
更多





?长春氟宁生物活性












































描述
Vinflunine是新型氟化长春花生物碱，有阻断有丝分裂和微管蛋白相互作用的活性。
相关类别





溶解度

体外：

在DMSO中10mM


储备液

1 mM 1.2241 mL 6.1205 mL 12.2410 mL
5 mM 0.2448 mL 1.2241 mL 2.4482 mL
10 mM 0.1224 mL 0.6120 mL 1.2241 mL


存储

请将产品存放在分析证书中的建议条件下。


运输

室温;可能会有所不同
SMILES

CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C(C=C([C@](C4=C5C(C=CC=C6)=C6N4)(CC(C[C@@H](C(F)(F)C)C7)([H])CN7C5)C(OC)=O)C(OC)=C8)=C8N9C)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O
参考文献

[1]. Ngan, V.K., et al., Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. Cancer Res, 2000. 60(18): p. 5045-51.

[2]. Lobert, S., et al., Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line. Biochemistry, 2000. 39(39): p. 12053-62.

[3]. Kruczynski, A., et al., Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur J Cancer, 2006. 42(16): p. 2821-32.
相关活性
小分子



诺考达唑



|

一甲基澳瑞他汀E



|

VcMMAE



|

Mertansine(DM1化合物)



|

甲磺酸艾瑞布林



|

埃博霉素



|

酒石酸长春瑞滨



|

埃博霉素B



|

McMMAF



|

MMAF盐酸盐



|

伊沙匹隆



|

N,BETA,BETA-三甲基-L-苯基丙氨酰基-N-[(1S,2E)-3-羧基-1-(1-甲基乙基)-2-丁烯基]-N,3-二甲基-L-缬氨酰胺



|

雌莫司汀磷酸钠



|

安丝菌素P3



|

考布他丁 A-4 磷酸二钠盐






?长春氟宁物理化学性质




























密度 1.39 g/cm3
分子式 C45H54F2N4O8
分子量 816.92900
精确质量 816.39100
PSA 133.87000
LogP 5.01950
折射率 1.652










?长春氟宁上下游产品











长春氟宁上游产品? 1

长春氟宁下游产品? 0















?长春氟宁英文别名










































4′-Deoxy-20′


Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-15-[(12S,14R,16R)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraen-12-yl]-
 3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate


4′-Deoxy-20′,20′-difluoro-8′-norvincaleukoblastine


MFCD00938122


C’-Norvincaleukoblastine,4′-deoxy-20′,20′-difluoro


aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(4R,6R,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-


20′,20′-difluoro-3′,4′-dihydrovinorelbine


Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-15-[(12S,14R,16R)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraen-12-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate


C45H54F2N4O8


Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(4R,6R,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16 ;-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-


methyl (2β,3β,4β,5α,12β,19α)-4-(acetyloxy)-15-[(4R,6R,8S)-4-(1,1-difluoroethyl)-8-(methoxycarbonyl)-1,3,4,5,6,7,8,9-octahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate








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