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阿奇霉素 A
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| 中文名 |
阿奇霉素 A |
|---|---|
| 英文名 |
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one |
| 中文别名 |
9-去氧-9a-氮杂-同型红霉素A 去甲阿奇霉素 | 去甲阿奇霉素 | 阿奇霉素杂质 A |
| 英文别名 |
更多 |
| 描述 |
Azathramycin 是一种抗生素。 |
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| 相关类别 |
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| 溶解度 |
体外：
DMSO：33.33 mg / mL（45.35 mM;需要超声波） 体内：1。逐个添加每种溶剂：10％DMSO 90％（20％SBE-β-CD在盐水中）溶解度：≥2.5mg / mL（3.40 mM）;澄清溶液2.逐个添加每种溶剂：10％DMSO 90％玉米油溶解度：≥2.5mg / mL（3.40 mM）;澄清溶液3.逐个添加每种溶剂：10％DMSO 40％PEG300 5％吐温-80 45％盐水溶解度：≥2.5mg/ mL（3.40mM）;明确解决方案
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| 储备液 |
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| 存储 |
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| 运输 |
室温;可能会有所不同 |
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| SMILES |
C[C@H]1[C@H](O)[C@](C)(OC)C[C@]([H])(O[C@@H]([C@H](C)[C@@H](O[C@@]2([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@@](O)(C)[C@@H](CC)O3)[C@@H](C)C3=O)O1 |
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| 参考文献 |
[3]. Fernandez-Obregon AC. Azithromycin for the treatment of acne. Int J Dermatol. 2000 Jan;39(1):45-50.
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| 相关活性 小分子 |
嘌呤霉素盐酸盐 | G-418 硫酸盐 | 衣霉素 | 潮霉素B | 盐霉素 | 阿维巴坦钠 | 硫酸新霉素 | 法硼巴坦 | 甲氧西林钠 | 利福平 | 甲硝唑 | 羧苄青霉素钠 | 头孢他啶 | Eravacycline dihydrochloride | 头孢噻肟钠 |
| 密度 | 1.2±0.1 g/cm3 |
|---|---|
| 沸点 | 815.2±65.0 °C at 760 mmHg |
| 熔点 | 126-136?C |
| 分子式 | C37H70N2O12 |
| 分子量 | 734.958 |
| 闪点 | 446.8±34.3 °C |
| 精确质量 | 734.492859 |
| PSA | 188.87000 |
| LogP | 3.11 |
| 外观性状 | 白色固体 |
| 蒸汽压 | 0.0±0.6 mmHg at 25°C |
| 折射率 | 1.536 |
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~83%
阿奇霉素 A
76801-85-9
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文献：ALEMBIC LIMITED Patent: WO2009/156938 A2, 2009 ; Location in patent: Page/Page column 8 ; |
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~%
阿奇霉素 A
76801-85-9
|
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文献：WO2007/80507 A2, ; Page/Page column 11 ; |
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~44%
阿奇霉素 A
76801-85-9
|
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文献：Costa, Anna M.; Vilarrasa, Jaume Tetrahedron Letters, 2000 , vol. 41, # 18 p. 3371 – 3375 |
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~%
阿奇霉素 A
76801-85-9
|
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文献：Lee, Younjoo; Choi, Jun Yong; Fu, Hong; Harvey, Colin; Ravindran, Sandeep; Roush, William R.; Boothroyd, John C.; Khosla, Chaitan Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2792 – 2804 |
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~%
阿奇霉素 A
76801-85-9
|
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文献：Journal of Medicinal Chemistry, , vol. 54, # 8 p. 2792 – 2804 |
| 阿奇霉素 A上游产品? 3 | |
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| 阿奇霉素 A下游产品? 1 | |
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Peptide-mediated macrolide resistance reveals possible specific interactions in the nascent peptide exit tunnel. Mol. Microbiol. 54(2) , 376-85, (2004)
Expression of specific short peptides can render cells resistant to macrolide antibiotics. Peptides conferring resistance to structurally different macrolides including oleandomycin, azithromycin, aza…
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Quantitative thin-layer chromatographic method of analysis of azithromycin in pure and capsule forms. J. Chromatogr. Sci. 41(1) , 10-6, (2003)
A validated stability-indicating thin-layer chromatographic (TLC) method of the analysis of azithromycin (AZT) in bulk and capsule forms is developed. Both AZT potential impurity and degradation produ…
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Erythromycin series. XII. Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A: synthesis and structure-activity relationship of its acyl derivatives. J. Antibiot. 40(7) , 1006-15, (1987)
Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A (5), the new 15-membered semi-synthetic macrolide antibiotic with nitrogen as additional atom in the aglycone ring of eryt…
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9-deokso-9a-aza-9a-homoeritromicin A |
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Desmethylazithromycin |
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1-oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- |
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9a-N-desmethyl azithromycin |
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(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2, 6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside |
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DD-Azaerythromycin A |
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10-Dihydro-10-deoxo-11-azaerythromycin A |
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9-Deoxo-9a-aza-9a-homo Erythromycin A(Desmethyl Azithromycin) |
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(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside |
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9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A |
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9a-aza-9-deoxo-9a-homoerythromycin A |
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9-deoxo-9a-aza-9a-homoerythromycin |
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Azaerythromycin A |
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UNII-4LSP9FJT5B |
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1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β -D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- |
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9-deoxo-9a-aza-9a-homoerythromycin A |
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Azathramycin |
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