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阿福豆苷

阿福豆苷

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?阿福豆苷名称


















中文名

阿福豆苷
英文名

afzelin
中文别名


番泻叶山奈苷




|



山奈酚-3-O-a-L-吡喃鼠李糖苷



英文别名
更多





?阿福豆苷生物活性


































描述
Afzelin (Kaempferol-3-O-rhamnoside) 是一种在鱼腥草 (Houttuynia cordata) 中发现的黄酮醇糖苷，广泛用于制备抗菌剂，解热剂，解毒剂和治疗炎症。 Afzelin 减弱线粒体损伤，增强线粒体生物合成，降低线粒体相关蛋白，帕金和 PTEN 诱导的假定激酶 1 (putative kinase 1) 的水平。Afzelin 可提高 D-半乳糖胺 (GalN)/LPS 处理的小鼠的存活率，降低丙氨酸氨基转移酶和促炎细胞因子的血清水平。
相关类别





SMILES

O=C1C(O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)O)=C(C3=CC=C(O)C=C3)OC4=CC(O)=CC(O)=C14
参考文献

[1]. Lee SB, et al. Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. Br J Pharmacol. 2017 Jan;174(2):195-209.






?阿福豆苷物理化学性质



































密度 1.7±0.1 g/cm3
沸点 765.6±60.0 °C at 760 mmHg
分子式 C21H20O10
分子量 432.378
闪点 272.4±26.4 °C
精确质量 432.105652
PSA 170.05000
LogP 2.37
蒸汽压 0.0±2.7 mmHg at 25°C
折射率 1.748






?阿福豆苷安全信息
















危险品运输编码 NONH for all modes of transport





?阿福豆苷合成线路






















?阿福豆苷文献2

更多文献











Antibacterial effects of afzelin isolated from Cornus macrophylla on Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals.

Molecules 19(3) , 3173-80, (2014)

The crude ethyl acetate extract of the leaves of Cornus macrophylla showed antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals. Bioactivi…



Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage.

PLoS ONE 8(4) , e61971, (2013)

Ultraviolet (UV) radiation induces DNA damage, oxidative stress, and inflammatory processes in human keratinocytes, resulting in skin inflammation, photoaging, and photocarcinogenesis. Adequate protec…







?阿福豆苷英文别名
















































kaempferol 3-O-α-L-rhamnopyranoside


kaempferol-3-rhamnoside


5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-deoxy-α-L-mannopyranoside


5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one


4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-


Kaempferol-3-O-α-L-rhamnoside


Kaempferol 3-O-Alpha-L-Rhamnoside


Afzelin


Trihydroxy-SL0101


4H-1-Benzopyran-4-one, 3-((6-deoxy-α-L-mannopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-


Kaempferol 3-rhamnoside


3-O-α-rhamnosylkaempferol


Kaempferin








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