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骆驼蓬碱

骆驼蓬碱

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?骆驼蓬碱名称


















中文名

骆驼蓬碱
英文名

vasicine
中文别名


(R)-1,2,3,9-四氢吡咯并[2,1-B]喹唑啉-3-醇




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鸭嘴花碱




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哈尔明



英文别名
更多





?骆驼蓬碱生物活性


































描述
Vasicine (peganine) 是一种喹唑啉类生物碱,可从Justicia adhatoda 中分离得到。Vasicine (peganine) 具有抗结核活性。
相关类别


SMILES

O[C@H]1CCN2C1=NC3=C(C=CC=C3)C2
参考文献

[1]. Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50(1):49-53.







?骆驼蓬碱物理化学性质





































密度 1.1124
沸点 373.8±52.0 °C at 760 mmHg
熔点 211.5°C
分子式 C11H12N2O
分子量 188.226
闪点 179.9±30.7 °C
精确质量 188.094955
PSA 35.83000
LogP -1.00
蒸汽压 0.0±0.9 mmHg at 25°C
折射率 1.5850






?骆驼蓬碱MSDS







?骆驼蓬碱毒性和生态




骆驼蓬碱毒性英文版






?骆驼蓬碱安全信息
































符号

GHS07


GHS07
信号词
Warning
危害声明
H302
危害码 (欧洲)
Xn
风险声明 (欧洲)
22
危险品运输编码 UN 1544
包装等级 III
危险类别 6.1(b)
海关编码 2933990090














?骆驼蓬碱海关















海关编码 2933990090
中文概述 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%








?骆驼蓬碱文献25

更多文献














Potentiation of oxytocin evoked responses by (+) sotalol deoxysotalol and Vasicine HCl on isolated rat and rabbit uterus.

Indian J. Med. Res. 76 Suppl , 107-14, (1982)





Natural products as templates for bioactive compound libraries: part 2. Novel modifications of vasicine (peganine) core via efficient and regioselective generation of 3-lithiodeoxyvasicine and its stereoselective addition to aliphatic ketones section sign.

Nat. Prod. Res. 20(9) , 871-81, (2006)

A general procedure for direct lithiation of deoxyvasicine was developed. 3-Lithiodeoxyvasicine intermediate was found to react with various aliphatic ketones providing derivatives of 3-(hydroxyalkyl)…





Formulation and pharmacokinetic evaluation of hard gelatin capsule encapsulating lyophilized Vasa Swaras for improved stability and oral bioavailability of vasicine.

Fitoterapia 82(3) , 446-53, (2011)

The oral bioavailability of vasicine (1) was investigated in hard gelatin capsules of lyophilized Vasa Swaras (aqueous extract of Adhatoda vasica Nees.,Fam.: Acanthaceae) The rat pharmacokinetic profi…









?骆驼蓬碱英文别名

































Pyrrolo[2,1-b]quinazolin-3-ol, 1,2,3,9-tetrahydro-, (3R)-


Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro-


(R)-1,2,3,9-Tetrahydropyrrolo(2,1-b)quinazolin-3-ol


1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol


peganine


(3R)-1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol


Pyrrolo[2,1-b]quinazolin-3-ol, 1,2,3,9-tetrahydro-


vasicin








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