高车前素

IC50: 2.71 μM (Pim-1)[1]

DMSO：125 mg / mL（416.31 mM;需要超声波）

体内：1。逐个添加每种溶剂：10％DMSO 40％PEG300 5％吐温-80％45％盐水溶解度：≥2.08mg/ mL（6.93mM）;澄清溶液2.逐个加入各溶剂：10％DMSO 90％（20％SBE-β-CD在盐水中）溶解度：≥2.08mg/ mL（6.93mM）;澄清溶液3.逐个添加每种溶剂：10％DMSO 90％玉米油溶解度：≥2.08mg/ mL（6.93mM）;明确解决方案

[1]. Chao SW, et al. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene KinasePim-1. J Nat Prod. 2015 Aug 28;78(8):1969-76.

[2]. Gao H, et al. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Cell Biochem Biophys. 2014 May;69(1):27-34.

[3]. Zhou R, et al. Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway. Cell Biochem Biophys. 2014 Jun;69(2):311-7.

[4]. Lin TY, et al. Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats. Eur J Pharmacol. 2015 May 15;755:6-15.

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:3

3.氢键受体数量:6

4.可旋转化学键数量:2

5.互变异构体数量:57

6.拓扑分子极性表面积:96.2

7.重原子数量:22

8.表面电荷:0

9.复杂度:454

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

J. Agric. Food Chem. 47(11) , 4579-82, (1999)

A reversed-phase HPLC procedure is proposed for the determination of seven flavonoids (luteolin, nepetin, hispidulin, jaceosidin, cirsimaritin, cirsilineol, and eupatorin) in vervain samples. A simple...

Zhongguo Yao Li Xue Bao 15(5) , 385-8, (1994)

Two flavones, 4′,5,7-trihydroxy-6-methoxy flavone (dinatin) and 4′,5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the bin…

J. Pharm. Biomed. Anal. 48(1) , 100-4, (2008)

To control the quality of Salvia plebeia R.Br., a simple and reliable method of high-performance liquid chromatography coupled with photodiode array detector (HPLC-DAD) was developed both for fingerpr…