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麦角硫因

麦角硫因

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?麦角硫因名称


















中文名

麦角硫因
英文名

ergothioneine
中文别名


2-巯基组氨酸甜菜碱



英文别名
更多





?麦角硫因生物活性


































描述
Ergothioneine 是组氨酸甜菜碱的咪唑-2-硫酮衍生物,是由某些细菌和真菌合成的。Ergothioneine 通常被认为是抗氧化剂。
相关类别



SMILES

S=C1NC(C[C@@H](C([O-])=O)[N+](C)(C)C)=CN1
参考文献

[1]. Oumari M, et al. Regeneration of ergothioneine after reaction with singlet oxygen. Free Radic Biol Med. 2019 Apr;134:498-504.







?麦角硫因物理化学性质




























熔点 275-277?C (dec.)
分子式 C9H15N3O2S
分子量 229.299
精确质量 229.088501
PSA 100.97000
LogP -3.43
外观性状 白色固体






?麦角硫因安全信息





















个人防护装备
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport
WGK德国 3














?麦角硫因文献43

更多文献














Effect of mushroom diet on pharmacokinetics of gabapentin in healthy Chinese subjects.

Br. J. Clin. Pharmacol. 78(1) , 129-34, (2014)

This study evaluated the pharmacokinetics of gabapentin in Chinese subjects who received a diet rich in shiitake mushrooms. Shiitake mushrooms have been shown to contain high amount of ergothioneine. …





The Aspergillus fumigatus protein GliK protects against oxidative stress and is essential for gliotoxin biosynthesis.

Eukaryotic Cell 11(10) , 1226-38, (2012)

The function of a number of genes in the gliotoxin biosynthetic cluster (gli) in Aspergillus fumigatus remains unknown. Here, we demonstrate that gliK deletion from two strains of A. fumigatus complet…





Uptake and protective effects of ergothioneine in human endothelial cells.

J. Pharmacol. Exp. Ther. 350(3) , 691-700, (2014)

Ergothioneine is a thiourea derivative of histidine found in food, especially mushrooms. Experiments in cell-free systems and chemical assays identified this compound as a powerful antioxidant. Experi…









?麦角硫因英文别名





































































ergothioneine


L-Ergothioneine


(2S)-3-(2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)-2-(trimethylammonio)propanoate


[(S)-1-carboxy-2-(2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-ethyl]-trimethyl-ammonium,betaine


Thiolhistidine betaine


Sympectothion


(S)-a-Carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-1H-imidazole-4-ethanaminium Hydroxide Inner Salt


L(+)-Ergothioneine


Thiotane


2-thiol-L-histidine-betaine


1H-Imidazole-4-ethanaminium, α-carboxy-2-mercapto-N,N,N-trimethyl-, inner salt, (αS)-


[(S)-1-Carboxy-2-(2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-aethyl]-trimethyl-ammonium,Betain


Ammonium, [1-carboxy-2-(2-thioxo-4-imidazolin-4-yl)ethyl]trimethyl-, hydroxide, inner salt


(2S)-3-(2-Sulfanyl-1H-imidazol-5-yl)-2-(trimethylammonio)propanoate


[1-Carboxy-2-[2-mercaptoimidazol-4(or 5)-yl]ethyl]trimethylammonium Hydroxide Inner Salt


thiotaine


Thiasine


1H-imidazole-5-ethanaminium, α-carboxy-2-mercapto-N,N,N-trimethyl-, inner salt, (αS)-


Thiolhistidine-βine


Phytothioneine








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