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[10]-姜酚

[10]-姜酚

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?[10]-姜酚名称


















中文名

[10]-姜酚
英文名

[10]-Gingerol
中文别名


10-姜酮醇




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(S)-5-羟基-1-(4-羟基-3-甲氧基苯基)十四烷-3-酮




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10-姜辣醇




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10-姜酚



英文别名
更多





?[10]-姜酚生物活性


































描述
10-Gingerol 是姜根脂的一种主要刺激性成分,具有抗炎、抗氧化和抗增殖活性。10-Gingerol 能抑制 MDA-MB-231 肿瘤细胞的增殖,其 IC50 值为 12.1 μM。
相关类别




SMILES

CCCCCCCCC[C@H](O)CC(CCC1=CC=C(O)C(OC)=C1)=O
参考文献

[1]. Dugasani S, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010 Feb 3;127(2):515-20.

[2]. Almada da Silva J, et al. Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:157-62.







?[10]-姜酚物理化学性质









































密度 1.0±0.1 g/cm3
沸点 499.7±35.0 °C at 760 mmHg
熔点 45 – 46 °C
分子式 C21H34O4
分子量 350.492
闪点 166.4±19.4 °C
精确质量 350.245697
PSA 66.76000
LogP 4.61
蒸汽压 0.0±1.3 mmHg at 25°C
折射率 1.513
储存条件 2-8°C
水溶解性 methanol: soluble5mg/mL, clear, colorless






?[10]-姜酚MSDS







?[10]-姜酚毒性和生态




[10]-姜酚毒性英文版






?[10]-姜酚安全信息
























危害声明
H413
风险声明 (欧洲)
53
安全声明 (欧洲)
24/25
危险品运输编码 NONH for all modes of transport
海关编码 2914509090





?[10]-姜酚合成线路
















?[10]-姜酚海关















海关编码 2914509090
中文概述 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 丙酮报明包装
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%








?[10]-姜酚文献3

更多文献














Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.

J. Pharm. Pharmacol. 67(4) , 583-96, (2015)

To determine the reaction kinetics for regioselective glucuronidation of gingerols (i.e. 6-, 8- and 10-gingerol) by human liver microsomes and expressed UDP-glucuronosyltransferase (UGT) enzymes, and …





Identification of serotonin 5-HT1A receptor partial agonists in ginger.

Bioorg. Med. Chem. 18 , 3345-51, (2010)

Animal studies suggest that ginger (Zingiber officinale Roscoe) reduces anxiety. In this study, bioactivity-guided fractionation of a ginger extract identified nine compounds that interact with the hu…





Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).

J. Nat. Prod. 72 , 950-3, (2009)

In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3)…









?[10]-姜酚英文别名



























(S)- 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone


(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone


(5s)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one


<10>-Gingerol


10-Gingerol


3-Tetradecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-








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