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16,16-Dimethyl prostaglandin E2
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| 描述 |
16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) 是一种具有口服活性的脊椎动物造血干细胞 (HSCs) 稳态关键调节剂。16,16-Dimethyl prostaglandin E2 可以通过 EP2/EP4 起作用，并与 Wnt 途径相互作用。 |
|---|---|
| 相关类别 |
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| 靶点 |
EP2
EP4
|
| 体内研究 |
16,16-二甲基前列腺素E2（16,16-二甲基PGE2；10微克/千克；i.p.；每12小时；连续8天）拯救Tpl2IMF-KO小鼠恶化的DSS结肠炎表型，并恢复上皮增殖和结构[2]。动物模型：Tpl2IMF-KO小鼠[2]剂量：10μg/kg给药：IP；每12小时一次；连续8天结果：挽救了DSS结肠炎加重的表型，恢复了上皮细胞增殖和结构。 |
| 存储 |
请将产品存放在分析证书中的建议条件下。
|
| 运输 |
室温 |
| SMILES |
CCCCC(C)([C@@H](/C=C/[C@@H]1[C@@H](C/C=CCCCC(O)=O)C(C[C@H]1O)=O)O)C |
| 参考文献 |
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| 密度 | 1.1±0.1 g/cm3 |
|---|---|
| 沸点 | 541.3±50.0 °C at 760 mmHg |
| 熔点 | -85.6?C |
| 分子式 | C22H36O5 |
| 分子量 | 380.518 |
| 闪点 | 295.2±26.6 °C |
| 精确质量 | 380.256287 |
| PSA | 94.83000 |
| LogP | 2.57 |
| 蒸汽压 | 0.0±3.3 mmHg at 25°C |
| 折射率 | 1.551 |
|
16,16-Dimethyl prostaglandin E2毒性英文版
|
| 符号 |
GHS02, GHS07 |
|---|---|
| 信号词 |
Danger |
| 危害声明 |
H225-H319-H336 |
| 补充危害声明 |
Repeated exposure may cause skin dryness or cracking. |
| 警示性声明 |
P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235 |
| 个人防护装备 |
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| 危害码 (欧洲) |
F,Xn,Xi |
| 风险声明 (欧洲) |
11-20/21/22-36/37/38-67-66-36 |
| 安全声明 (欧洲) |
16-26-36 |
| 危险品运输编码 | UN 1231 3/PG 2 |
|
~%
16,16-Dimethyl ...
39746-25-3
|
|
文献：Rodriguez, Ana; Nomen, Miguel; Spur, Bernd W.; Godfroid, Jean-Jacques Archiv der Pharmazie, 1998 , vol. 331, # 9 p. 279 - 282 |
|
~%
16,16-Dimethyl ...
39746-25-3
|
|
文献：Rodriguez, Ana; Nomen, Miguel; Spur, Bernd W.; Godfroid, Jean-Jacques Archiv der Pharmazie, 1998 , vol. 331, # 9 p. 279 - 282 |
|
~%
16,16-Dimethyl ...
39746-25-3
|
|
文献：Rodriguez, Ana; Nomen, Miguel; Spur, Bernd W.; Godfroid, Jean-Jacques Archiv der Pharmazie, 1998 , vol. 331, # 9 p. 279 - 282 |
|
~%
16,16-Dimethyl ...
39746-25-3
|
|
文献：Rodriguez, Ana; Nomen, Miguel; Spur, Bernd W.; Godfroid, Jean-Jacques Archiv der Pharmazie, 1998 , vol. 331, # 9 p. 279 - 282 |
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| 16,16-Dimethyl prostaglandin E2上游产品? 2 | |
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| 16,16-Dimethyl prostaglandin E2下游产品? 1 | |
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Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic conditions. Sci. Rep. 5 , 16406, (2015)
Several clinical trials are exploring therapeutic effect of human CD34(+) cells in ischemic diseases, including myocardial infarction. Unfortunately, most of the cells die few days after delivery. Her…
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Prostaglandin E2–mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control. Circulation 110(16) , 2326-32, (2004)
In the preterm newborn, a patent ductus arteriosus is in large part a result of the increased sensitivity of the immature ductus to prostaglandin E2 (PGE2). PGE2 acts through 3 G protein-coupled recep…
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Prostanoids regulate angiogenesis acting primarily on IP and EP4 receptors. Microvasc. Res. 101 , 127-34, (2015)
Angiogenesis is regulated by numerous activators and inhibitors, including prostanoids. Although many studies have identified their roles in inflammation, regulatory functions of prostanoids in angiog…
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(5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1-oic acid |
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Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (5Z,11α,13E,15R)- |
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16,16-Dimethyl Prostaglandin E2,(5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oicacid |
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