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4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二甲酸甲基(1-丁酰氧基)甲酯

4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二甲酸甲基(1-丁酰氧基)甲酯

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?名称


















中文名

4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二甲酸甲基(1-丁酰氧基)甲酯
英文名

5-O-(butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
中文别名


氯维地平




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丁酸氯维地平




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氯维地平丁酸酯/丁酸氯维地平



英文别名
更多





?生物活性












































描述
Clevidipine 是短效二氢吡啶钙离子通道拮抗剂,IC50为7.1 nM。
相关类别



溶解度

体外:

DMSO:≥50mg / mL(109.57 mM)

* “≥”表示可溶,但饱和度未知。

体内:1。逐个添加每种溶剂:10%DMSO 90%玉米油溶解度:≥2.5mg / mL(5.48 mM);澄清溶液2.逐个加入各溶剂:10%DMSO 40%PEG300 5%吐温-80 45%盐水溶解度:≥2.5mg/ mL(5.48mM);明确解决方案

储备液

1 mM 2.1914 mL 10.9572 mL 21.9144 mL
5 mM 0.4383 mL 2.1914 mL 4.3829 mL
10 mM 0.2191 mL 1.0957 mL 2.1914 mL


存储

4°C,避光


运输

室温;可能会有所不同
SMILES

O=C(C1=C(C)NC(C)=C(C(OCOC(CCC)=O)=O)C1C2=CC=CC(Cl)=C2Cl)OC
参考文献

[1]. Yi X, Vivien B, Lynch C 3rd. Clevidipine blockade of L-type Ca2+ currents: steady-state and kinetic electrophysiological studies in guinea pigventricular myocytes.

[2]. Huraux C, Makita T, Szlam F, The vasodilator effects of clevidipine on human internal mammary artery. Anesth Analg. 1997 Nov;85(5):1000-4.

[3]. Ericsson H, et al. In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolised by esterases, in different animal species and man. Eur J Pharm Sci. 1999 Apr;8(1):29-37.

[4]. Ericsson H, et al. Pharmacokinetics of new calcium channel antagonist clevidipine in the rat, rabbit, and dog and pharmacokinetic/pharmacodynamic relationship in anesthetized dogs. Drug Metab Dispos. 1999 May;27(5):558-64.

[5]. Schwieler JH, et al. Circulatory effects and pharmacology of clevidipine, a novel ultra short acting and vascular selective calcium antagonist, in hypertensive humans. J Cardiovasc Pharmacol. 1999 Aug;34(2):268-74.


相关活性
小分子




硫酸新霉素



|

硝苯地平



|

氯化乙酰胆碱



|

罗红霉素



|

Bay-K-8644((S)-(-)-)



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尼莫地平



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米贝拉地尔



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左乙拉西坦



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CDN1163



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丹曲林钠



|

毒胡萝卜素



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氟芬那酸



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ABT-639



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盐酸雷诺嗪



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色甘酸钠






?物理化学性质







































密度 1.3±0.1 g/cm3
沸点 539.7±50.0 °C at 760 mmHg
熔点 128-130°C
分子式 C21H23Cl2NO6
分子量 456.316
闪点 280.2±30.1 °C
精确质量 455.090240
PSA 90.93000
LogP 5.46
蒸汽压 0.0±1.4 mmHg at 25°C
折射率 1.543
储存条件 Refrigerator






?安全信息
















安全声明 (欧洲)
24/25
















?英文别名













































(butanoyloxy)methyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate


Cleviprex


clevidipine


(±)-Hydroxymethyl Methyl 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate Butyrate (Ester)


Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate


Clevidipine butyrate


Clevidipine,Cleviprex


H 324/38


(Butyryloxy)methyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate


Clevelox


3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl (1-oxobutoxy)methyl ester


rac-Clevidipine








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