7-木糖基紫杉醇

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中文名	7-木糖基-紫杉醇
英文名	(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate
中文别名	7-木糖基紫杉醇
英文别名	更多

描述

7-xylosyltaxol(Taxol-7-xyloside)是紫杉醇衍生物。

相关类别

信号通路 >>

细胞周期/DNA损伤 >>

微管/微管蛋白

信号通路 >>

细胞骨架 >>

微管/微管蛋白

天然产物 >>

萜类化合物和糖苷

研究领域 >>

癌症

溶解度

体外：

在DMSO中10mM

储备液

1 mM	1.0142 mL	5.0709 mL	10.1418 mL
5 mM	0.2028 mL	1.0142 mL	2.0284 mL
10 mM	0.1014 mL	0.5071 mL	1.0142 mL

存储

请将产品存放在分析证书中的建议条件下。

运输

室温;可能会有所不同

SMILES

O=C(C1=CC=CC=C1)N[C@@H](C2=CC=CC=C2)[C@@H](O)C(O[C@@H]3C(C)=C([C@@H](OC(C)=O)C([C@@]4(C)[C@]([C@](OC(C)=O)(CO5)[C@@]5([H])C[C@@H]4O[C@@]6([H])[C@H](O)[C@@H](O)[C@H](O)CO6)([H])[C@@H]7OC(C8=CC=CC=C8)=O)=O)C(C)(C)[C@@]7(O)C3)=O

参考文献

[1]. Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in cultivated and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7.

[2]. Chao Z, Tan M, Paudel MK, et al. Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel. J Nat Med. 2012 Sep 25.

[3]. Park SJ, Wu CH, Gordon JD, et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3;279(49):51057-67. Epub 2004 Sep 27.

[4]. Rao S, He L, Chakravarty S, et al. Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol. J Biol Chem. 1999 Dec 31;274(53):37990-4.

[5]. Paclitaxel

相关活性
小分子

密度	1.5±0.1 g/cm3
沸点	1062.3±65.0 °C at 760 mmHg
分子式	C₅₂H₅₉NO₁₈
分子量	986.021
闪点	596.3±34.3 °C
精确质量	985.373230
LogP	7.81
蒸汽压	0.0±0.3 mmHg at 25°C
折射率	1.646

Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13- tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate

Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13- tetramethyl-5-oxo-4-(D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate

benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

7-Xylosyltaxol

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7-木糖基紫杉醇

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