8-异戊烯基柚皮素

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中文名	8-异戊烯基柚皮素
英文名	8-Prenylnaringenin
英文别名	更多

描述	8-prenylnaringenin 是一种从啤酒花穗 (Humulus lupulus) 中分离到的异戊烯类黄酮，具有细胞毒性。8-prenylnaringenin 能通过诱导内源性、外源性通路介导的凋亡，对 HCT-116 结肠癌细胞产生抗增殖活性。8-Prenylnaringenin 能通过激活小鼠 Akt 磷酸化途径，促进其从静止诱导的停用性肌肉萎缩中恢复。
相关类别	信号通路 >> 细胞凋亡 >> 细胞凋亡研究领域 >> 癌症
SMILES	O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=C(C/C=C(C)C)C(O)=CC(O)=C13
参考文献	[1]. Koosha S, et al. Antiproliferative and apoptotic activities of 8-prenylnaringenin against human colon cancer cells. Life Sci. 2019 Jul 3:116633. [2]. Mukai R, et al. 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1022-R1031. [3]. Stompor M, et al. In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells-Cellular Accumulation and Cytotoxicity. Molecules. 2017 Jun 30;22(7).

密度	1.3±0.1 g/cm3
沸点	597.6±50.0 °C at 760 mmHg
分子式	C₂₀H₂₀O₅
分子量	340.370
闪点	216.4±23.6 °C
精确质量	340.131073
PSA	86.99000
LogP	5.28
蒸汽压	0.0±1.8 mmHg at 25°C
折射率	1.642
储存条件	2-8°C

危险品运输编码	NONH for all modes of transport

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8-Prenylnaringenin

5,7-Dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-chromen-4-one

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-

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8-异戊烯基柚皮素

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