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beta-乳香酸
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| 描述 |
β-Boswellic acid 是从乳香 Boswellia serrate 的树胶脂中分离出来的。β-Boswellic acid 是 5-脂氧合酶 (5-LO) 产物形成的非还原型抑制剂，其直接与 5-LO 相互作用或阻断其易位。β-Boswellic acid 抑制人白血病 HL-60 细胞中 DNA，RNA和蛋白质的合成。 |
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| 相关类别 |
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| SMILES |
C[C@]12[C@@](CC=C3[C@]2(CC[C@]4(C)[C@@]3([H])[C@H]([C@H](C)CC4)C)C)([H])[C@@]5([C@@]([C@](C)([C@H](O)CC5)C(O)=O)([H])CC1)C |
| 参考文献 |
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| 密度 | 1.1±0.1 g/cm3 |
|---|---|
| 沸点 | 556.0±50.0 °C at 760 mmHg |
| 熔点 | 130-135?C |
| 分子式 | C30H48O3 |
| 分子量 | 456.700 |
| 闪点 | 304.1±26.6 °C |
| 精确质量 | 456.360352 |
| PSA | 57.53000 |
| LogP | 9.38 |
| 外观性状 | 灰白色固体 |
| 蒸汽压 | 0.0±3.4 mmHg at 25°C |
| 折射率 | 1.555 |
| 危险品运输编码 | NONH for all modes of transport |
|---|---|
| 海关编码 | 2918199090 |
| 海关编码 | 2918199090 |
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| 中文概述 | HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0% |
| 申报要素 | 品名, 成分含量, 用途 |
| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs. Bioorg. Med. Chem. Lett. 22 , 431-5, (2012)
Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines…
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A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid. Eur. J. Med. Chem. 46 , 1356-66, (2011)
Semi-synthetic analogues of β-boswellic acid (BA) and 11-keto-β-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical c…
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The “MESACA” study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv. Ther. 28(10) , 894-906, (2011)
Osteoarthritis is a chronic rheumatoid disease mediated by metalloproteinases and inflammatory cytokines. Methylsulfonylmethane (MSM) and boswellic acids (BA) each show promise in the treatment of inf…
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b-Boswellic Acid |
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β-BOSWELLIC ACID |
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(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14bR)-3-Hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-4-picenecarboxylic acid |
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Urs-12-en-24-oic acid, 3-hydroxy-, (3α,9ξ)- |
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(3a,4b)-3-Hydroxyurs-12-en-23-oic Acid |
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(3α,9ξ)-3-Hydroxyurs-12-en-24-oic acid |
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