GTS-21二盐酸盐(DMBX-A)

USD$0.00

品牌商品推荐

更多 >>

聚[(N,N'-(4-正丁基苯基)-N,N'-二苯基-1,4-苯二胺)-ALT-(9,9-二正辛基芴基-2,7-二基)]
(1S,2S,3AR,4R,4AS,4BS,6R,8S,8AS,9AR,10R,10AR)-十二氢-2,4A,6,9A-四甲基环戊二烯并[B]芴-1,3A,4,6,8,8A,10(1H,4H)-七醇 4,8,8A,10-四乙酸酯 1-苯甲酸酯
硫酸奎尼丁
依替膦酸钠
成核透明剂 TH-3988
4-Methyl-6-nitro-1H-indazole

商品详情

客户评价

中文名	(1:2),(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3-联吡啶盐酸盐
英文名	3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl
中文别名	(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3′-联吡啶二盐酸盐
英文别名	更多

描述

GTS-21二盐酸盐是一种选择性α7烟碱型乙酰胆碱受体 (α7nAChR) 激动剂。

相关类别

信号通路 >>

跨膜转运 >>

胆碱受体

信号通路 >>

神经信号通路 >>

胆碱受体

研究领域 >>

炎症/免疫

溶解度

体外：

DMSO：16.5 mg / mL（43.27 mM;需要超声波和加热）

储备液

1 mM	2.6226 mL	13.1130 mL	26.2261 mL
5 mM	0.5245 mL	2.6226 mL	5.2452 mL
10 mM	0.2623 mL	1.3113 mL	2.6226 mL

存储

粉末	-20℃下	3年
	4℃下	2年
在溶剂中	-80℃下	6个月
	-20℃下	1个月

运输

室温;可能会有所不同

SMILES

COC1=CC(OC)=CC=C1/C=C2CCCN=C2C3=CC=CN=C3.Cl[H].Cl[H]

参考文献

[1]. Yue Y, et al. GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor. Int Immunopharmacol. 2015 Dec;29(2):504-12.

[2]. Nullens S, et al. EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE. Shock. 2016 Apr;45(4):450-9.

相关活性
小分子

密度	1.1±0.1 g/cm3
沸点	485.6±45.0 °C at 760 mmHg
熔点	216-217℃ (decomposition)
分子式	C₁₉H₂₂Cl₂N₂O₂
分子量	381.30
闪点	247.5±28.7 °C
PSA	43.71000
LogP	2.64
外观性状	powder,faint yellow to dark yellow
蒸汽压	0.0±1.2 mmHg at 25°C
折射率	1.580
储存条件	2-8°C
水溶解性	H2O: >5mg/mL

危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	DW1764860
海关编码	2933399090

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Central muscarinic cholinergic activation alters interaction between splenic dendritic cell and CD4+CD25- T cells in experimental colitis.

PLoS ONE 9(10) , e109272, (2014)

The cholinergic anti-inflammatory pathway (CAP) is based on vagus nerve (VN) activity that regulates macrophage and dendritic cell responses in the spleen through alpha-7 nicotinic acetylcholine recep…

Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

Br. J. Pharmacol. 172 , 5123-35, (2015)

α7 nicotinic acetylcholine receptors (α7 nAChRs) may represent useful targets for cognitive improvement. The aim of this study is to compare the pro-cognitive activity of selective α7-nAChR ligands, i…

The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia.

J. Neuroimmunol. 251(1-2) , 65-72, (2012)

The anti-inflammatory properties of, particularly the α7, nicotinic acetylcholine receptors (nAChRs) in the peripheral immune system are well documented. There are also reports of anti-inflammatory ac…

3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl

3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride

3-(2,4-dimethoxybenzylidene)anabaseine

2,3′-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, (3E)-

3-(2,4-Dimethoxybenzyl)-3,4,5,6-tetrahydro-2,3′-bipyridine

(3E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3′-bipyridine

3-(2,4)-DiMethoxybenzylidineanabaseine

GTS-21

DMXB-A

GTS 21 2HCl

GTS-21 (dihydrochloride)

Tags:

This product was successfully added to cart!

GTS-21二盐酸盐(DMBX-A)

品牌商品推荐

聚[(N,N'-(4-正丁基苯基)-N,N'-二苯基-1,4-苯二胺)-ALT-(9,9-二正辛基芴基-2,7-二基)]

(1S,2S,3AR,4R,4AS,4BS,6R,8S,8AS,9AR,10R,10AR)-十二氢-2,4A,6,9A-四甲基环戊二烯并[B]芴-1,3A,4,6,8,8A,10(1H,4H)-七醇 4,8,8A,10-四乙酸酯 1-苯甲酸酯

硫酸奎尼丁

依替膦酸钠

成核透明剂 TH-3988

4-Methyl-6-nitro-1H-indazole

商品详情

客户评价